Check Point Cell Lines

 

Regulation of immune responses is tightly controlled through a balance of co-stimulatory and inhibitory checkpoint receptors often exploited by many cancers. Therefore, therapeutics that block inhibitory receptors or activate immune-stimulatory checkpoint receptors, such as PD-1 receptor, have proven to be powerful agents to restore anti-tumor immune responses.

 

ScreeNingBio offers a large, diverse selection of assays for characterization, screening, and potency QC lot-release testing of immunotherapy therapeutics targeting both inhibitory and co-stimulatory checkpoint receptors. Utilize functional mechanism of action (MOA)-reflective cell-based checkpoint receptor assays to analyze signaling, dimerization, internalization, and clustering/crosslinking of checkpoint receptors. These simple, rapid assays provide a highly sensitive response for most targets without primary cells or complex protocols in a few hours.